[HTML][HTML] Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
Activation of the interferon regulatory factors (IRFs) 3 and 7 transcription factors is essential
for the induction of type I interferon (IFN) and development of the innate antiviral response.
Retinoic acid-inducible gene I has been shown to contribute to virus-induced IFN production
independent of the Toll-like receptor pathways in response to a variety of RNA viruses and
double-stranded RNA. In the present study, we demonstrate that the NF-κB-inducible, anti-
apoptotic protein A20 efficiently blocks RIG-I-mediated activation of NF-κB-, IRF-3-, and IRF …
for the induction of type I interferon (IFN) and development of the innate antiviral response.
Retinoic acid-inducible gene I has been shown to contribute to virus-induced IFN production
independent of the Toll-like receptor pathways in response to a variety of RNA viruses and
double-stranded RNA. In the present study, we demonstrate that the NF-κB-inducible, anti-
apoptotic protein A20 efficiently blocks RIG-I-mediated activation of NF-κB-, IRF-3-, and IRF …