Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the PPAR family of
transcription factors. Synthetic PPARγ agonists are used as oral anti-hyperglycemic drugs
for the treatment of non-insulin-dependent diabetes. However, emerging evidence indicates
that PPARγ activators can also prevent or attenuate neurodegeneration. Given these
previous findings, the focus of this report is on the potential neuroprotective role of PPARγ
activation in preventing the loss of mitochondrial function in Huntington disease (HD). For …