[PDF][PDF] A multivariate analysis of patients with brain tumors treated with ATN-RNA

E Wyszko, K Rolle, S Nowak, R Zukiel, M Nowak… - Acta Pol …, 2008 - academia.edu
E Wyszko, K Rolle, S Nowak, R Zukiel, M Nowak, R Piestrzeniewicz, I Gawrońska…
Acta Pol Pharm, 2008academia.edu
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized
by genetic instability, intratumoral histopathological variability, and unpredictable clinical
behavior. Malignant gliomas express preferentially a number of surface markers that may be
exploited as therapeutic targets, such as tenascin-C, an extracellular matrix glycoprotein
contributes to tumor cell adhesion, invasion, migration and proliferation. Disappointing
results in the treatment of gliomas with surgery, radiation and chemotherapy have fuelled a …
Abstract
Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. Malignant gliomas express preferentially a number of surface markers that may be exploited as therapeutic targets, such as tenascin-C, an extracellular matrix glycoprotein contributes to tumor cell adhesion, invasion, migration and proliferation. Disappointing results in the treatment of gliomas with surgery, radiation and chemotherapy have fuelled a search for new treatment modalities. Here we present the data for 46 patients suffering from brain tumor. They were resected and treated with dsRNA (ATN-RNA) complementary to the sequence of tenascin-C mRNA. MRI and CT follow up studies showed growth tumor delay or lack of its recurrence symptoms, due to inhibition of TN-C synthesis. A significant improvement in overall survival (OS) was observed without loosing of the quality of life (QOL) of patients. This novel therapy based on RNA interference shows a big therapeutical potential. To our knowledge intervention with RNAi (iRNAi) is the first protocol of application of RNAi in human disease treatment.
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