Is tetrabenazine safe and effective for suppressing chorea in Huntington's disease?
BR Leavitt, MR Hayden - Nature Clinical Practice Neurology, 2006 - nature.com
BR Leavitt, MR Hayden
Nature Clinical Practice Neurology, 2006•nature.comBackground Chorea in Huntington's disease (HD) is often treated with neuroleptics such as
haloperidol, but some patients develop extrapyramidal side effects with these drugs. In many
countries, the dopamine-depleting agent tetrabenazine is also used to treat chorea, but to
date its efficacy has only been shown in open-label studies. Objective To investigate the
safety, efficacy and dose tolerability of tetrabenazine for treating chorea in HD in a
randomized controlled fashion.
haloperidol, but some patients develop extrapyramidal side effects with these drugs. In many
countries, the dopamine-depleting agent tetrabenazine is also used to treat chorea, but to
date its efficacy has only been shown in open-label studies. Objective To investigate the
safety, efficacy and dose tolerability of tetrabenazine for treating chorea in HD in a
randomized controlled fashion.
Synopsis
Background
Chorea in Huntington's disease (HD) is often treated with neuroleptics such as haloperidol, but some patients develop extrapyramidal side effects with these drugs. In many countries, the dopamine-depleting agent tetrabenazine is also used to treat chorea, but to date its efficacy has only been shown in open-label studies.
Objective
To investigate the safety, efficacy and dose tolerability of tetrabenazine for treating chorea in HD in a randomized controlled fashion.
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