The oculomotor deficits associated with Huntington's Disease (HD) are one of the earliest
signs of disease onset. They include a marked delay in executing voluntary saccades and a
difficulty inhibiting saccades to task-irrelevant stimuli. In addition, HD patients develop a
deficit in task-switching, which can be demonstrated by the continued adherence to a rule
after it has been recently changed. These deficits are likely to be the result of a progressive
neural degeneration of the fronto-striatal system, which is a distinguishing feature of HD …