T-cell regulation in rheumatoid arthritis

JJ Goronzy, CM Weyand - Current opinion in rheumatology, 2004 - journals.lww.com
JJ Goronzy, CM Weyand
Current opinion in rheumatology, 2004journals.lww.com
The successful treatment trial of RA with CTLA-4Ig clearly documents the importance of T-
cell costimulation in RA disease activity. Novel costimulatory pathways may be of even
greater significance than CD28 in RA and may represent promising new therapeutic targets.
The finding of reduced thymic activity in RA is exciting and will stimulate further studies of T-
cell homeostasis and the function of regulatory cells.
Summary
The successful treatment trial of RA with CTLA-4Ig clearly documents the importance of T-cell costimulation in RA disease activity. Novel costimulatory pathways may be of even greater significance than CD28 in RA and may represent promising new therapeutic targets. The finding of reduced thymic activity in RA is exciting and will stimulate further studies of T-cell homeostasis and the function of regulatory cells.
Lippincott Williams & Wilkins