The mechanisms of action of disease-modifying antirheumatic drugs: a review with emphasis on macrophage signal transduction and the induction of proinflammatory …
J Bondeson - General Pharmacology: The Vascular System, 1997 - Elsevier
1. Rheumatoid arthritis (RA) is probably the most common source of treatable disability. A
major problem in modern rheumatology is that the mechanism (s) of action of the currently
used disease-modifying antirheumatic drugs (DMARDs) remain unclear. Many of these
drugs entered rheumatology mainly through clinical intuition and have been used for
decades. 2. 2. The former T-cell-centered paradigm of rheumatoid inflammation has given
way to a model of inflammation highlighting the macrophage and its proinflammatory …
major problem in modern rheumatology is that the mechanism (s) of action of the currently
used disease-modifying antirheumatic drugs (DMARDs) remain unclear. Many of these
drugs entered rheumatology mainly through clinical intuition and have been used for
decades. 2. 2. The former T-cell-centered paradigm of rheumatoid inflammation has given
way to a model of inflammation highlighting the macrophage and its proinflammatory …