The genetic and molecular basis of Fanconi anemia
JP de Winter, H Joenje - Mutation Research/Fundamental and Molecular …, 2009 - Elsevier
The capacity to maintain genomic integrity is shared by all living organisms. Multiple
pathways are distinguished that safeguard genomic stability, most of which have originated
in primitive life forms. In human individuals, defects in these pathways are typically
associated with cancer proneness. The Fanconi anemia pathway, one of these pathways,
has evolved relatively late during evolution and exists–in its fully developed form–only in
vertebrates. This pathway, in which thus far 13 distinct proteins have been shown to …
pathways are distinguished that safeguard genomic stability, most of which have originated
in primitive life forms. In human individuals, defects in these pathways are typically
associated with cancer proneness. The Fanconi anemia pathway, one of these pathways,
has evolved relatively late during evolution and exists–in its fully developed form–only in
vertebrates. This pathway, in which thus far 13 distinct proteins have been shown to …