On the origins of ultra-fine anaphase bridges
KL Chan, ID Hickson - Cell Cycle, 2009 - Taylor & Francis
KL Chan, ID Hickson
Cell Cycle, 2009•Taylor & FrancisOn the origins of ultra-fine anaphase bridges Page 1 www.landesbioscience.com Cell Cycle
3065 cohesion, could induce non-FA-associated UFBs on chromosome arms. The second
type of UFB forms between a pair of FANCD2/I foci that already exist on the sister-chromatids
in late S-phase/G2.These are rarely detected in untreated cells. However, they can be induced
by challenging cells with low doses of aphidicolin, an agent frequently used to induce
chromosome fragility. FA-associated UFBs are not found at centromeres, but instead localize …
3065 cohesion, could induce non-FA-associated UFBs on chromosome arms. The second
type of UFB forms between a pair of FANCD2/I foci that already exist on the sister-chromatids
in late S-phase/G2.These are rarely detected in untreated cells. However, they can be induced
by challenging cells with low doses of aphidicolin, an agent frequently used to induce
chromosome fragility. FA-associated UFBs are not found at centromeres, but instead localize …
Comment on: Chan KL, Palmai-Pallag T, Ying S, Hickson ID. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol 2009; 11:753-60.
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