TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity

T Kreslavsky, AK Savage, R Hobbs… - Proceedings of the …, 2009 - National Acad Sciences
T Kreslavsky, AK Savage, R Hobbs, F Gounari, R Bronson, P Pereira, PP Pandolfi
Proceedings of the National Academy of Sciences, 2009National Acad Sciences
Some γδ and αβ T lymphocytes exhibit an “innate” phenotype associated with rapid cytokine
responses. The PLZF transcription factor is essential for the innate phenotype of NKT cells.
This report shows that PLZF is likewise responsible for the innate, NKT-like phenotype of
Vγ1+ Vδ6. 3/Vδ6. 4+ cells. TCR cross-linking induced PLZF expression in all polyclonal
immature γδ thymocytes, suggesting that agonist selection might be required for PLZF
induction. Transgenic expression of Vγ1Vδ6. 4 TCR was sufficient to support the …
Some γδ and αβ T lymphocytes exhibit an “innate” phenotype associated with rapid cytokine responses. The PLZF transcription factor is essential for the innate phenotype of NKT cells. This report shows that PLZF is likewise responsible for the innate, NKT-like phenotype of Vγ1+Vδ6.3/Vδ6.4+ cells. TCR cross-linking induced PLZF expression in all polyclonal immature γδ thymocytes, suggesting that agonist selection might be required for PLZF induction. Transgenic expression of Vγ1Vδ6.4 TCR was sufficient to support the development of large numbers of PLZF+ T cells, further supporting the importance of the TCR for PLZF induction. Interestingly, expression of this TCR transgene led to the development of spontaneous dermatitis.
National Acad Sciences