[PDF][PDF] The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

RJ DeBerardinis, JJ Lum, G Hatzivassiliou… - Cell metabolism, 2008 - cell.com
RJ DeBerardinis, JJ Lum, G Hatzivassiliou, CB Thompson
Cell metabolism, 2008cell.com
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all
macromolecular components during each passage through the cell cycle. It is therefore not
surprising that metabolic activities in proliferating cells are fundamentally different from those
in nonproliferating cells. This review examines the idea that several core fluxes, including
aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a
stereotyped platform supporting proliferation of diverse cell types. We also consider …
Summary
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis.
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