Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin
LE Cohen, FE Wondisford, S Radovick - Endocrinology and metabolism …, 1996 - Elsevier
Pit-1, also termed growth hormone factor-1 (GHF-1), is a pituitary-specific transcription factor
responsible for pituitary development and hormone expression in mammals. It is a member
of the POU family of transcription factors, which, like homeotic proteins, belongs to the helix-
turn-helix superfamily of proteins and plays a fundamental role in mammalian
development53. POU is an acronym for Pit-1, Oct-1 that is widely expressed, Oct-2 that is
expressed in B lymphocytes and in certain areas of the brain, and Unc-86 that functions in …
responsible for pituitary development and hormone expression in mammals. It is a member
of the POU family of transcription factors, which, like homeotic proteins, belongs to the helix-
turn-helix superfamily of proteins and plays a fundamental role in mammalian
development53. POU is an acronym for Pit-1, Oct-1 that is widely expressed, Oct-2 that is
expressed in B lymphocytes and in certain areas of the brain, and Unc-86 that functions in …