The DNA damage response: putting checkpoints in perspective
BBS Zhou, SJ Elledge - Nature, 2000 - nature.com
BBS Zhou, SJ Elledge
Nature, 2000•nature.comThe inability to repair DNA damage properly in mammals leads to various disorders and
enhanced rates of tumour development. Organisms respond to chromosomal insults by
activating a complex damage response pathway. This pathway regulates known responses
such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been
shown to control additional processes including direct activation of DNA repair networks.
enhanced rates of tumour development. Organisms respond to chromosomal insults by
activating a complex damage response pathway. This pathway regulates known responses
such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been
shown to control additional processes including direct activation of DNA repair networks.
Abstract
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.
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