t (12; 21): a new recurrent translocation in acute lymphoblastic leukemia
SP Romana, ML Coniat… - Genes, Chromosomes and …, 1994 - Wiley Online Library
SP Romana, ML Coniat, R Berger
Genes, Chromosomes and Cancer, 1994•Wiley Online LibraryAbstract A t (12; 21)(p11‐p12; q22) was detected by chromosome painting in three patients
with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐abnormalities.
The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence
in situ hybridization (FISH) experiments using YAC clones from 21q21‐q22 were performed
to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.
2 in one patient. Although only one case of ALL with t (12; 21) has been reported previously …
with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐abnormalities.
The three leukemias had similar immunophenotypes (DR+, CD10+, CD19+). Fluorescence
in situ hybridization (FISH) experiments using YAC clones from 21q21‐q22 were performed
to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.
2 in one patient. Although only one case of ALL with t (12; 21) has been reported previously …
Abstract
A t(12;21)(p11 ‐p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight ALL cases with 12p‐ abnormalities. The three leukemias had similar immunophenotypes (DR+, CD10 +, CD19 + ). Fluorescence in situ hybridization (FISH) experiments using YAC clones from 21q21‐q22 were performed to better localize the breakpoint on chromosome 21. This breakpoint was localized to 21q22.2 in one patient. Although only one case of ALL with t( 12;21) has been reported previously, the present results suggest that t( 12;21) is a recurrent translocation in ALL. Genes Chrom Cancer 9:186‐191 (1994). © 1994 Wiley‐Liss, Inc.
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