Acute generalized exanthematous pustulosis associated with STI571 in a patient with chronic myeloid leukemia

MC Brouard, C Prins, S Mach-Pascual, JH Saurat - Dermatology, 2001 - karger.com
MC Brouard, C Prins, S Mach-Pascual, JH Saurat
Dermatology, 2001karger.com
The tyrosine kinase inhibitor STI571 is a novel promising class of anticancer drugs. We
report a case of cutaneous adverse reactions to STI571 in a young woman with blast crisis of
chronic myeloid leukemia. She had first typical acute generalized exanthematous pustulosis
mimicking mercury rash and then urticarial eruption. We suggest that cell pathways
mediated by some tyrosine kinases might be involved in the pathogenesis of these skin
eruptions.
Abstract
The tyrosine kinase inhibitor STI571 is a novel promising class of anticancer drugs. We report a case of cutaneous adverse reactions to STI571 in a young woman with blast crisis of chronic myeloid leukemia. She had first typical acute generalized exanthematous pustulosis mimicking mercury rash and then urticarial eruption. We suggest that cell pathways mediated by some tyrosine kinases might be involved in the pathogenesis of these skin eruptions.
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