Recent progress in basic research has enhanced our understanding of the molecular
mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter
variants contribute to an entire spectrum of cholestatic liver diseases and can cause
hereditary cholestatic syndromes or determine susceptibility and disease progression in
acquired cholestatic disorders. Cholestasis is associated with complex transcriptional and
post-transcriptional alterations of hepatobiliary transporters and enzymes participating in …