[HTML][HTML] Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages: a transcriptional role for specific oxysterols
A Venkateswaran, JJ Repa, JMA Lobaccaro… - Journal of Biological …, 2000 - ASBMB
To identify genes that are transcriptionally activated when human macrophages accumulate
excess lipids, we employed the mRNA differential display technique using RNA isolated
from human monocyte-macrophages incubated in the absence or presence of acetylated
low density lipoprotein and sterols (cholesterol and 25-hydroxycholesterol). These studies
identified a mRNA whose levels were highly induced in lipid-loaded macrophages. The
mRNA encoded the human White protein, a member of the ATP-binding cassette (ABC) …
excess lipids, we employed the mRNA differential display technique using RNA isolated
from human monocyte-macrophages incubated in the absence or presence of acetylated
low density lipoprotein and sterols (cholesterol and 25-hydroxycholesterol). These studies
identified a mRNA whose levels were highly induced in lipid-loaded macrophages. The
mRNA encoded the human White protein, a member of the ATP-binding cassette (ABC) …