Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity.
However, despite their excellent efficacy, severe side effects frequently limit the use of these
drugs. The search for novel glucocorticoids with reduced side effects has been intensified by
the discovery of new molecular details regarding the function of the glucocorticoid receptor.
These new insights may pave the way for novel, safer therapies that retain the efficacy of
currently prescribed steroids.