[HTML][HTML] Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells
OBJECTIVE: Although increased expression of CD38 on the surface of human CD34+ cells
is associated with differentiation, we reported recently that both lineage-negative (Lin−)
CD34+ CD38− and Lin− CD34+ CD38lo fractions of cord blood contain primitive severe
combined immunodeficient (SCID)–repopulating cells (SRC). Thus, it is important to
determine if a hierarchical relationship exists between the SRC from these two populations
or if CD38 is reversibly expressed. MATERIALS AND METHODS: To determine if SRC from …
is associated with differentiation, we reported recently that both lineage-negative (Lin−)
CD34+ CD38− and Lin− CD34+ CD38lo fractions of cord blood contain primitive severe
combined immunodeficient (SCID)–repopulating cells (SRC). Thus, it is important to
determine if a hierarchical relationship exists between the SRC from these two populations
or if CD38 is reversibly expressed. MATERIALS AND METHODS: To determine if SRC from …
