[HTML][HTML] Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice
K Isoda, S Sawada, M Ayaori, T Matsuki, R Horai… - Journal of Biological …, 2005 - ASBMB
Although the anti-inflammatory effect of interleukin-1 (IL-1) receptor antagonist (IL-1Ra) has
been described, the contribution of this cytokine to cholesterol metabolism remains unclear.
Our aim was to ascertain whether deficiency of IL-1Ra deteriorates cholesterol metabolism
upon consumption of an atherogenic diet. IL-1Ra-deficient mice (IL-1Ra-/-) showed severe
fatty liver and portal fibrosis containing many inflammatory cells following 20 weeks of an
atherogenic diet when compared with wild type (WT) mice. Expectedly, the levels of total …
been described, the contribution of this cytokine to cholesterol metabolism remains unclear.
Our aim was to ascertain whether deficiency of IL-1Ra deteriorates cholesterol metabolism
upon consumption of an atherogenic diet. IL-1Ra-deficient mice (IL-1Ra-/-) showed severe
fatty liver and portal fibrosis containing many inflammatory cells following 20 weeks of an
atherogenic diet when compared with wild type (WT) mice. Expectedly, the levels of total …