[HTML][HTML] Hypoxia-inducible factor-1α, a key factor in the keratinocyte response to UVB exposure
HR Rezvani, S Dedieu, S North, F Belloc… - Journal of Biological …, 2007 - ASBMB
Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor sensitive to oxygen levels,
which responds to stress factors under both hypoxic and nonhypoxic conditions. UV
irradiation being a common stressor of skin, we looked at the effect of UVB on HIF-1α
expression in keratinocytes. We found that UVB induces a biphasic HIF-1α variation through
reactive oxygen species (ROS) generation. Whereas rapid production of cytoplasmic ROS
down-regulates HIF-1α expression, delayed mitochondrial ROS generation results in its up …
which responds to stress factors under both hypoxic and nonhypoxic conditions. UV
irradiation being a common stressor of skin, we looked at the effect of UVB on HIF-1α
expression in keratinocytes. We found that UVB induces a biphasic HIF-1α variation through
reactive oxygen species (ROS) generation. Whereas rapid production of cytoplasmic ROS
down-regulates HIF-1α expression, delayed mitochondrial ROS generation results in its up …