[HTML][HTML] Platelet adhesion to dimeric β2‐glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibα and apolipoprotein E receptor 2 …
MTT Pennings, R Derksen, M Van Lummel… - Journal of Thrombosis …, 2007 - Elsevier
Background: The major antigen implicated in the antiphospholipid syndrome is beta2‐
glycoprotein I (β 2 GPI). Dimerized β 2 GPI binds to apolipoprotein E receptor
2′(apoER2′) on platelets and increases platelet adhesion to collagen under conditions of
flow. Aim: To investigate whether the interaction between dimerized β 2 GPI and platelets is
sufficiently strong to resist shear stresses. Methods: We studied the interaction of platelets
with immobilized dimerized β 2 GPI under conditions of flow, and further analyzed the …
glycoprotein I (β 2 GPI). Dimerized β 2 GPI binds to apolipoprotein E receptor
2′(apoER2′) on platelets and increases platelet adhesion to collagen under conditions of
flow. Aim: To investigate whether the interaction between dimerized β 2 GPI and platelets is
sufficiently strong to resist shear stresses. Methods: We studied the interaction of platelets
with immobilized dimerized β 2 GPI under conditions of flow, and further analyzed the …