hOCT 1 and resistance to imatinib
LC Crossman, BJ Druker, MWN Deininger - Blood, 2005 - ashpublications.org
LC Crossman, BJ Druker, MWN Deininger
Blood, 2005•ashpublications.orgImatinib is a substrate for the adenosine triphosphate–binding cassette (ABC) transporters
ABCB11-3 and ABCG24, 5; however, it is unclear whether these transporters influence
patients' responses to imatinib. Thomas et al6 recently reported on the active transport of
imatinib into cells by the human organic cation transporter 1 (hOCT1). They proposed that in
patients with chronic myeloid leukemia (CML), the differential expression of hOCT1 and
other drug transporters might be a critical determinant of intracellular drug levels, and hence …
ABCB11-3 and ABCG24, 5; however, it is unclear whether these transporters influence
patients' responses to imatinib. Thomas et al6 recently reported on the active transport of
imatinib into cells by the human organic cation transporter 1 (hOCT1). They proposed that in
patients with chronic myeloid leukemia (CML), the differential expression of hOCT1 and
other drug transporters might be a critical determinant of intracellular drug levels, and hence …
Imatinib is a substrate for the adenosine triphosphate–binding cassette (ABC) transporters ABCB11-3 and ABCG24, 5; however, it is unclear whether these transporters influence patients’ responses to imatinib. Thomas et al6 recently reported on the active transport of imatinib into cells by the human organic cation transporter 1 (hOCT1). They proposed that in patients with chronic myeloid leukemia (CML), the differential expression of hOCT1 and other drug transporters might be a critical determinant of intracellular drug levels, and hence influence response to imatinib.
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