Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses
M Hatta, P Gao, P Halfmann, Y Kawaoka - Science, 2001 - science.org
M Hatta, P Gao, P Halfmann, Y Kawaoka
Science, 2001•science.orgIn 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong,
killing 6 of the 18 people infected. When mice were infected with the human isolates, two
virulence groups became apparent. Using reverse genetics, we showed that a mutation at
position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high
cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal
infection.
killing 6 of the 18 people infected. When mice were infected with the human isolates, two
virulence groups became apparent. Using reverse genetics, we showed that a mutation at
position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high
cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal
infection.
In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
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