[HTML][HTML] Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions

AI Chen, AJ McAdam, JE Buhlmann, S Scott… - Immunity, 1999 - cell.com
AI Chen, AJ McAdam, JE Buhlmann, S Scott, ML Lupher, EA Greenfield, PR Baum…
Immunity, 1999cell.com
The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a
potential costimulatory molecule and also has been implicated in T cell homing and B cell
activation. To ascertain the essential functions of Ox40L, we generated and characterized
Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity
response, a dendritic cell–dependent T cell–mediated response, due to defects in T cell
priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T …
Abstract
The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To ascertain the essential functions of Ox40L, we generated and characterized Ox40L-deficient mice. Mice lacking Ox40L exhibit an impaired contact hypersensitivity response, a dendritic cell–dependent T cell–mediated response, due to defects in T cell priming and cytokine production. In contrast, Ox40L-deficient mice do not have defects in T cell homing or humoral immune responses. In vitro, Ox40L-deficient dendritic cells are defective in costimulating T cell cytokine production. Thus, Ox40L has a critical costimulatory function in vitro and in vivo for dendritic cell:T cell interactions.
cell.com