[HTML][HTML] GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
E Beauchamp, G Bulut, O Abaan, K Chen… - Journal of Biological …, 2009 - ASBMB
Ewing sarcoma family of tumors (ESFT) is an undifferentiated neoplasm of the bone and soft
tissue. ESFT is characterized by a specific chromosomal translocation occurring between
chromosome 22 and (in most cases) chromosome 11, which generates an aberrant
transcription factor, EWS-FLI1. The function of EWS-FLI1 is essential for the maintenance of
ESFT cell survival and tumorigenesis. The Hedgehog pathway is activated in several
cancers. Oncogenic potential of the Hedgehog pathway is mediated by increasing the …
tissue. ESFT is characterized by a specific chromosomal translocation occurring between
chromosome 22 and (in most cases) chromosome 11, which generates an aberrant
transcription factor, EWS-FLI1. The function of EWS-FLI1 is essential for the maintenance of
ESFT cell survival and tumorigenesis. The Hedgehog pathway is activated in several
cancers. Oncogenic potential of the Hedgehog pathway is mediated by increasing the …