[HTML][HTML] Gli2 is targeted for ubiquitination and degradation by β-TrCP ubiquitin ligase

N Bhatia, S Thiyagarajan, I Elcheva, M Saleem… - Journal of Biological …, 2006 - ASBMB
The Hedgehog (Hh) signaling pathway plays a crucial role in embryogenesis and has been
linked to the development of several human malignancies. The transcription factor Gli2 plays
a key role in the transduction of Hh signals by modulating transcription of some Hh target
genes, yet the mechanisms that control Gli2 protein expression are largely unknown. Here
we report that β-transducin repeat-containing protein (β-TrCP) E3 ubiquitin ligase is required
for Gli2 degradation. β-TrCP2 directly binds wild type Gli2 and promotes its ubiquitination …