Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin αvβ3
XP Zhang, T Kamata, K Yokoyama… - Journal of Biological …, 1998 - ASBMB
MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/
cysteine-rich protein, is expressed on the surface of a wide range of cells and has an RGD
tripeptide in its disintegrin-like domain. MDC-15 is potentially involved in cell-cell
interactions through its interaction with integrins. We expressed a recombinant MDC-15
disintegrin-like domain as a fusion protein with glutathione S-transferase (designated D-15)
in bacteria and examined its binding function to integrins using mammalian cells expressing …
cysteine-rich protein, is expressed on the surface of a wide range of cells and has an RGD
tripeptide in its disintegrin-like domain. MDC-15 is potentially involved in cell-cell
interactions through its interaction with integrins. We expressed a recombinant MDC-15
disintegrin-like domain as a fusion protein with glutathione S-transferase (designated D-15)
in bacteria and examined its binding function to integrins using mammalian cells expressing …
