Reactive oxygen species (ROS) are constantly generated and eliminated in the biological
system, and play important roles in a variety of normal biochemical functions and abnormal
pathological processes. Growing evidence suggests that cancer cells exhibit increased
intrinsic ROS stress, due in part to oncogenic stimulation, increased metabolic activity, and
mitochondrial malfunction. Since the mitochondrial respiratory chain (electron transport
complexes) is a major source of ROS generation in the cells, the vulnerability of the …