[HTML][HTML] Protective effects of catalase overexpression on UVB-induced apoptosis in normal human keratinocytes
HR Rezvani, F Mazurier, M Cario-André, C Pain… - Journal of Biological …, 2006 - ASBMB
UV-induced apoptosis in keratinocytes is a highly complex process in which various
molecular pathways are involved. These include the extrinsic pathway via triggering of death
receptors and the intrinsic pathway via DNA damage and reactive oxygen species (ROS)
formation. In this study we investigated the effect of catalase and CuZn-superoxide
dismutase (SOD) overexpression on apoptosis induced by UVB exposure at room
temperature or 4° C on normal human keratinocytes. Irradiation at low temperature reduced …
molecular pathways are involved. These include the extrinsic pathway via triggering of death
receptors and the intrinsic pathway via DNA damage and reactive oxygen species (ROS)
formation. In this study we investigated the effect of catalase and CuZn-superoxide
dismutase (SOD) overexpression on apoptosis induced by UVB exposure at room
temperature or 4° C on normal human keratinocytes. Irradiation at low temperature reduced …