Regulation of apoptosis by insulin-like growth factor (IGF)-I

R Kooijman - Cytokine & growth factor reviews, 2006 - Elsevier
IGF-I is important for fetal and post-natal development, but it also controls tissue
homeostasis throughout life via regulation of cell proliferation and apoptosis. This review
summarizes our current understanding of how IGF-I receptor signaling interferes with the
apoptotic machinery of the cell. IGF-I acts at different control points of apoptosis, including
the Bcl-2 family proteins, inhibitors of caspases and signaling of death-inducing receptors.
The main focal point of IGF-I is the regulation of Bcl-2 family proteins. Several signaling …