Persistent prostate-specific antigen expression after neoadjuvant androgen depletion: an early predictor of relapse or incomplete androgen suppression
CJ Ryan, A Smith, P Lal, J Satagopan, V Reuter… - Urology, 2006 - Elsevier
OBJECTIVES: To analyze post-androgen depletion (AD) primary tumors to identify markers
of treatment failure because AD does not reduce the probability of prostate-specific antigen
(PSA) failure after prostatectomy. METHODS: Tumors removed by radical prostatectomy
after 3 months of AD from 21 patients were analyzed for gene expression using
oligonucleotide arrays. Differences between patients with and without relapse were
identified using a conservative significance criteria of a threefold change and delta 0.68 …
of treatment failure because AD does not reduce the probability of prostate-specific antigen
(PSA) failure after prostatectomy. METHODS: Tumors removed by radical prostatectomy
after 3 months of AD from 21 patients were analyzed for gene expression using
oligonucleotide arrays. Differences between patients with and without relapse were
identified using a conservative significance criteria of a threefold change and delta 0.68 …