[HTML][HTML] Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production
JS Millar, SJ Stone, UJF Tietge, B Tow… - Journal of lipid …, 2006 - ASBMB
Increased triglyceride synthesis resulting from enhanced flux of fatty acids into liver is
frequently associated with VLDL overproduction. This has led to the common belief that
hepatic triglyceride synthesis can directly modulate VLDL production. We used adenoviral
vectors containing either murine acyl-coenzyme A: diacylglycerol transferase 1 (DGAT1) or
DGAT2 cDNA to determine the effect of a short-term increase in hepatic triglyceride
synthesis on VLDL triglyceride and apolipoprotein B (apoB) production in female wild-type …
frequently associated with VLDL overproduction. This has led to the common belief that
hepatic triglyceride synthesis can directly modulate VLDL production. We used adenoviral
vectors containing either murine acyl-coenzyme A: diacylglycerol transferase 1 (DGAT1) or
DGAT2 cDNA to determine the effect of a short-term increase in hepatic triglyceride
synthesis on VLDL triglyceride and apolipoprotein B (apoB) production in female wild-type …