Quantitative measurement of infectious murine cytomegalovirus genomes in real-time PCR

RL Wheat, PY Clark, MG Brown - Journal of virological methods, 2003 - Elsevier
Acute virus replication in murine (M) CMV infected C57BL/6 (Cmv1r) mice is severely limited
by Ly49H+ NK cells, but not in MCMV infected BALB/c or BXD8 (Cmv1s) mice that lack
Ly49H+ NK cells. Interestingly, other NK cell receptors may also play a role in MCMV
immunity, as CMV encoded gp40 protein can diminish expression of protein ligands
recognized by the NK cell receptor NKG2D. To determine whether other additional gene
products might influence MCMV immunity, we designed an efficient, sensitive and reliable …