The two hats of SOS
A Nimnual, D Bar-Sagi - Science's STKE, 2002 - science.org
A Nimnual, D Bar-Sagi
Science's STKE, 2002•science.orgSon of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in
response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide
exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and
Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be
recruited to different cellular locations through interactions with the adaptor proteins Grb2
and E3b1.
response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide
exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and
Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be
recruited to different cellular locations through interactions with the adaptor proteins Grb2
and E3b1.
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be recruited to different cellular locations through interactions with the adaptor proteins Grb2 and E3b1.
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