[HTML][HTML] Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants
F Sun, R Zhang, X Gong, X Geng, PF Drain… - Journal of Biological …, 2006 - ASBMB
A complex involving Derlin-1 and p97 mediates the retrotranslocation and endoplasmic
reticulum (ER)-associated degradation of misfolded proteins in yeast and is used by certain
viruses to promote host cell protein degradation (Romisch, K.(2005) Annu. Rev. Cell Dev.
Biol. 21, 435-456; Lilley, BN, and Ploegh, HL (2004) Nature 429, 834-840; Ye, Y., Shibata,
Y., Yun, C., Ron, D., and Rapoport, TA (2004) Nature 429, 841-847). We asked whether the
components of this pathway are involved in the endoplasmic reticulum-associated …
reticulum (ER)-associated degradation of misfolded proteins in yeast and is used by certain
viruses to promote host cell protein degradation (Romisch, K.(2005) Annu. Rev. Cell Dev.
Biol. 21, 435-456; Lilley, BN, and Ploegh, HL (2004) Nature 429, 834-840; Ye, Y., Shibata,
Y., Yun, C., Ron, D., and Rapoport, TA (2004) Nature 429, 841-847). We asked whether the
components of this pathway are involved in the endoplasmic reticulum-associated …