[HTML][HTML] Role for p300 in stabilization of p53 in the response to DNA damage
ZM Yuan, Y Huang, T Ishiko, S Nakada… - Journal of Biological …, 1999 - ASBMB
The nuclear p300/CBP proteins function as coactivators of gene transcription. Here, using
cells deficient in p300 or CBP, we show that p300, and not CBP, is essential for ionizing
radiation-induced accumulation of the p53 tumor suppressor and thereby p53-mediated
growth arrest. The results demonstrate that deficiency of p300 results in increased
degradation of p53. Our findings suggest that p300 contributes to the stabilization and
transactivation function of p53 in the cellular response to DNA damage.
cells deficient in p300 or CBP, we show that p300, and not CBP, is essential for ionizing
radiation-induced accumulation of the p53 tumor suppressor and thereby p53-mediated
growth arrest. The results demonstrate that deficiency of p300 results in increased
degradation of p53. Our findings suggest that p300 contributes to the stabilization and
transactivation function of p53 in the cellular response to DNA damage.