The differential gene expression profiles of proximal and distal muscle groups are altered in pre-pathological dysferlin-deficient mice
M von der Hagen, SH Laval, LM Cree, F Haldane… - Neuromuscular …, 2005 - Elsevier
The selective pattern of muscle involvement is a key feature of muscular dystrophies.
Dysferlinopathy is a good model for studying this process since it shows variable muscle
involvement that can be highly selective even in individual patients. The transcriptomes of
proximal and distal muscles from wildtype C57BL/10 and dysferlin deficient C57BL/10. SJL-
Dysf mice at a prepathological stage were assessed using the Affymetrix oligonucleotide-
microarray system. We detected significant variation in gene expression between proximal …
Dysferlinopathy is a good model for studying this process since it shows variable muscle
involvement that can be highly selective even in individual patients. The transcriptomes of
proximal and distal muscles from wildtype C57BL/10 and dysferlin deficient C57BL/10. SJL-
Dysf mice at a prepathological stage were assessed using the Affymetrix oligonucleotide-
microarray system. We detected significant variation in gene expression between proximal …