Formation of metastasis by human breast carcinoma cells (MCF-7) in nude mice
SM Shafie, LA Liotta - Cancer Letters, 1980 - Elsevier
SM Shafie, LA Liotta
Cancer Letters, 1980•ElsevierMCF-7 cells, a human breast carcinoma line, forms tumors when injected into athymic nude
mice. These tumors are able to metastasize to lungs, liver and spleen. 17β-estradiol
treatment increases both the growth rate and frequency of metastases. Castration or
diabetes prevents metastasis formation, but treatment with estrogen or insulin restores the
metastasizing capacity. MCF-7 cells secrete into the culture media collagenases able to lyse
types I and IV collagens. Estrogen or insulin addition to the culture enhances collagenase …
mice. These tumors are able to metastasize to lungs, liver and spleen. 17β-estradiol
treatment increases both the growth rate and frequency of metastases. Castration or
diabetes prevents metastasis formation, but treatment with estrogen or insulin restores the
metastasizing capacity. MCF-7 cells secrete into the culture media collagenases able to lyse
types I and IV collagens. Estrogen or insulin addition to the culture enhances collagenase …
Abstract
MCF-7 cells, a human breast carcinoma line, forms tumors when injected into athymic nude mice. These tumors are able to metastasize to lungs, liver and spleen. 17β-estradiol treatment increases both the growth rate and frequency of metastases. Castration or diabetes prevents metastasis formation, but treatment with estrogen or insulin restores the metastasizing capacity.
MCF-7 cells secrete into the culture media collagenases able to lyse types I and IV collagens. Estrogen or insulin addition to the culture enhances collagenase production. Attention is called to the coexistence of enhancement in collagenase production and metastasis formation.
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