[HTML][HTML] A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
C Pigeon, G Ilyin, B Courselaud, P Leroyer… - Journal of biological …, 2001 - ASBMB
Considering that the development of hepatic lesions related to iron overload diseases might
be a result of abnormally expressed hepatic genes, we searched for new genes up-
regulated under the condition of iron excess. By suppressive subtractive hybridization
performed between livers from carbonyl iron-overloaded and control mice, we isolated a 225-
base pair cDNA. By Northern blot analysis, the corresponding mRNA was confirmed to be
overexpressed in livers of experimentally (carbonyl iron and iron-dextran-treated mice) and …
be a result of abnormally expressed hepatic genes, we searched for new genes up-
regulated under the condition of iron excess. By suppressive subtractive hybridization
performed between livers from carbonyl iron-overloaded and control mice, we isolated a 225-
base pair cDNA. By Northern blot analysis, the corresponding mRNA was confirmed to be
overexpressed in livers of experimentally (carbonyl iron and iron-dextran-treated mice) and …