Liver plays a major role in regulating energy homeostasis in mammals. During feeding
conditions, excessive glucose is converted into a preferred storage form of energy sources
as triacylglycerol in liver via a collective metabolic pathway termed lipogenesis. Sterol
regulatory element-binding protein 1c is a master regulator for this process by activating
number of enzyme genes, such as Fasn or Acaca, that are involved in this pathway at the
transcriptional level. Here we show that the salt-inducible kinase (SIK) family of proteins …