Lung neutrophil burden correlates with increased pro-inflammatory cytokines and decreased lung function in individuals with α1-antitrypsin deficiency
F Rouhani, G Paone, NK Smith, P Krein, P Barnes… - Chest, 2000 - journal.chestnet.org
1AT, NE-1AT complexes, antineutrophil elastase capacity (ANEC), and interleukin (IL)-8, IL-
1, and IL-6 in BAL fluid. Twentytwo individuals with 1AT deficiency and mild functional lung
impairment (mean FEV1, 101 3.0% of predicted) were compared with 14 normal individuals
(mean FEV1, 107 4.0% of predicted). Enzyme-linked immunosorbent assays were used for
all measurements, and the actual epithelial lining fluid (ELF) concentration was estimated
using the urea method. There were significant differences in ELF concentrations of 1AT, NE …
1, and IL-6 in BAL fluid. Twentytwo individuals with 1AT deficiency and mild functional lung
impairment (mean FEV1, 101 3.0% of predicted) were compared with 14 normal individuals
(mean FEV1, 107 4.0% of predicted). Enzyme-linked immunosorbent assays were used for
all measurements, and the actual epithelial lining fluid (ELF) concentration was estimated
using the urea method. There were significant differences in ELF concentrations of 1AT, NE …