T0901317 is a dual LXR/FXR agonist
KA Houck, KM Borchert, CD Hepler, JS Thomas… - Molecular genetics and …, 2004 - Elsevier
We characterize the ability of the liver X receptor (LXRα [NR1H3] and LXRβ [NR1H2])
agonist, T0901317, to activate the farnesoid X receptor (FXR [NR4H4]). Although T0901317
is a much more potent activator of LXR than FXR, this ligand actually activates FXR more
potently than a natural bile acid FXR ligand, chenodeoxycholic acid. Thus, the FXR activity
of T0901317 must be considered when utilizing this agonist as a pharmacological tool to
investigate LXR function.
agonist, T0901317, to activate the farnesoid X receptor (FXR [NR4H4]). Although T0901317
is a much more potent activator of LXR than FXR, this ligand actually activates FXR more
potently than a natural bile acid FXR ligand, chenodeoxycholic acid. Thus, the FXR activity
of T0901317 must be considered when utilizing this agonist as a pharmacological tool to
investigate LXR function.