Leptin receptor and functional effects of leptin in human endothelial progenitor cells
R Wolk, A Deb, NM Caplice, VK Somers - Atherosclerosis, 2005 - Elsevier
Circulating endothelial progenitor cells (EPCs) may be involved in the maintenance of
vascular homeostasis and their impairment may be conducive to vascular disease. We
studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC
function. EPCs were grown from human circulating mononuclear cells. The presence of the
leptin receptor and the functional effects of leptin in EPCs were investigated. EPCs stained
positive for endothelial cell markers (Flk-1 and Tie-2 receptors) and the hematopoietic CD34 …
vascular homeostasis and their impairment may be conducive to vascular disease. We
studied the role of an adipocyte-derived hormone, leptin, in the regulation of human EPC
function. EPCs were grown from human circulating mononuclear cells. The presence of the
leptin receptor and the functional effects of leptin in EPCs were investigated. EPCs stained
positive for endothelial cell markers (Flk-1 and Tie-2 receptors) and the hematopoietic CD34 …