Effect of selenium supplementation on biochemical markers and outcome in critically ill patients
V Mishra, M Baines, SE Perry, PJ McLaughlin… - Clinical Nutrition, 2007 - Elsevier
BACKGROUND & AIMS: This study aimed to assess the effect of high dose selenium (Se)
supplementation on Se status in blood, oxidative stress, thyroid function and possible effects
on requirement for renal replacement therapy (RRT) in severely septic patients admitted to
the intensive care unit (ICU). METHODS: This prospective single-centre study was carried
out in 40 septic ICU patients who were randomized to high dose Se (Se+ group, N= 18 (474,
316,158 μg/day), each for 3 consecutive days followed by a standard dose of 31.6 μg/day of …
supplementation on Se status in blood, oxidative stress, thyroid function and possible effects
on requirement for renal replacement therapy (RRT) in severely septic patients admitted to
the intensive care unit (ICU). METHODS: This prospective single-centre study was carried
out in 40 septic ICU patients who were randomized to high dose Se (Se+ group, N= 18 (474,
316,158 μg/day), each for 3 consecutive days followed by a standard dose of 31.6 μg/day of …