Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea
C Riva, E Donadieu, J Magnan, JP Lavieille - Experimental gerontology, 2007 - Elsevier
Pathologies of senescence, in particular those of neurosensory organs represent an
important health problem. The improvement of the life expectation entails the fast increase of
the frequency of the age-related hearing loss (ARHL) in the population. There are numerous
factors that contribute to this process, which include altered vascular characteristics,
hypoxia/ischemia, genetic mutations and production of reactive oxygen species. We were
interested in understanding the mechanisms involved in the cochlear degeneration in a …
important health problem. The improvement of the life expectation entails the fast increase of
the frequency of the age-related hearing loss (ARHL) in the population. There are numerous
factors that contribute to this process, which include altered vascular characteristics,
hypoxia/ischemia, genetic mutations and production of reactive oxygen species. We were
interested in understanding the mechanisms involved in the cochlear degeneration in a …