Attenuated expression of SECIS binding protein 2 causes loss of telomeric reserve without affecting telomerase
The family of selenoproteins have a broad range of functions, including protection against
oxidative damage. Previous studies have shown that elevated levels of oxidative damage
can induce accelerated loss of telomeric DNA during proliferation of mammalian cells. The
incorporation of selenocysteine (Sec) into proteins in mammalian cells requires the Sec
insertion sequence (SECIS) binding protein 2 (SBP2). Thus in the present study we have
assessed the effect of knocking down the expression of SBP2 on telomere length. Following …
oxidative damage. Previous studies have shown that elevated levels of oxidative damage
can induce accelerated loss of telomeric DNA during proliferation of mammalian cells. The
incorporation of selenocysteine (Sec) into proteins in mammalian cells requires the Sec
insertion sequence (SECIS) binding protein 2 (SBP2). Thus in the present study we have
assessed the effect of knocking down the expression of SBP2 on telomere length. Following …