In mammals, the regulation of hepatic metabolism plays a key role in whole body energy
balance, since the liver is the major site of carbohydrate metabolism (glycolysis and
glycogen synthesis) and triglyceride synthesis (lipogenesis). Lipogenesis is regulated
through the acute control of key enzyme activities by means of allosteric and covalent
modifications. Moreover, the synthesis of most glycolytic and lipogenic enzymes is regulated
in response to dietary status, in which glucose, in particular, is a crucial energy nutrient. This …