The role of innate immunity in autoimmune tissue injury
In systemic lupus erythematosus, autoantibodies and expansion of autoreactive T cells
indicate systemic autoimmunity, but organ damage involves additional mechanisms of
inflammation and tissue remodelling. Targeting local release of proinflammatory cytokines,
for example, by blocking Toll-like receptors or single cytokines, may enhance treatment
efficacy in autoimmunity without increasing systemic immunosuppression.
indicate systemic autoimmunity, but organ damage involves additional mechanisms of
inflammation and tissue remodelling. Targeting local release of proinflammatory cytokines,
for example, by blocking Toll-like receptors or single cytokines, may enhance treatment
efficacy in autoimmunity without increasing systemic immunosuppression.
Summary
In systemic lupus erythematosus, autoantibodies and expansion of autoreactive T cells indicate systemic autoimmunity, but organ damage involves additional mechanisms of inflammation and tissue remodelling. Targeting local release of proinflammatory cytokines, for example, by blocking Toll-like receptors or single cytokines, may enhance treatment efficacy in autoimmunity without increasing systemic immunosuppression.
Lippincott Williams & Wilkins