Spinal α2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function
K Hayashida, JC Eisenach - The Journal of the American Society of …, 2010 - pubs.asahq.org
Introduction Spinal alpha2-adrenoceptor stimulation produces analgesia in neuropathic
pain states, and this effect in animals is blocked by the inhibitors of brain-derived
neurotrophic factor (BDNF) function. In rats, alpha2-adrenoceptor stimulation normally
inhibits acetylcholine release, but it excites release after nerve injury. The authors examined
the roles of BDNF and excitatory Gs-protein in this change. Methods Male rats underwent L5-
L6 spinal nerve ligation (SNL), and their lumbar spinal dorsal horns with or without spinal …
pain states, and this effect in animals is blocked by the inhibitors of brain-derived
neurotrophic factor (BDNF) function. In rats, alpha2-adrenoceptor stimulation normally
inhibits acetylcholine release, but it excites release after nerve injury. The authors examined
the roles of BDNF and excitatory Gs-protein in this change. Methods Male rats underwent L5-
L6 spinal nerve ligation (SNL), and their lumbar spinal dorsal horns with or without spinal …